INTERNATIONAL BURCH UNIVERSITY
Graduate Study - Faculty of Engineering and Natural Sciences
Genetics and Bioengineering PhD
2014-2015

SYLLABUS
Code Name Level Year Semester
GBE 622 Advanced Topics in Forensic DNA Analysis Graduate 1 Spring
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
6 154 English

Instructor Assistant Coordinator
Damir Marjanović, Prof. Dr. Damir Marjanović, Prof. Dr.
[email protected] no email

This course begins with the history and development of DNA typing and profiling for criminal and civil purposes. It discusses the statistical interpretation of results with case examples, mitochondrial DNA testing, Y single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs), and X-SNP and STR testing. It also explores low copy number DNA typing, mixtures, and quality assurance and control.

COURSE OBJECTIVE
Concept of genetic polymorphism.
Interpreting DNA results from forensic case studies.
Describing how gender, mitochondrial, and Y-chromosomal DNA analyses are performed.
Analyzing genetic diversity in human populations. Methods of DNA analysis in forensic genetics: RFLP, PCR, STR’s analysis. Basic forensic DNA laboratory procedures. CODIS, INTERPOL, European database. The newest technologies and its usage in the field of forensic genetics

COURSE CONTENT
Week
Topic
  1. Basic Genetics and Human Genetic Variation.
  2. Forensic DNA Analysis and Statistics.
  3. Forensic Aspects of mtDNA Analysis.
  4. Y Chromosome in Forensic Science.
  5. Forensic Application of X Chromosome STR s and SNPs.
  6. Low Copy Number DNA Profiling. Forensic DNA Mixtures, Approaches, and Analysis.
  7. Forensic DNA Typing and Quality Assurance. Collection and Preservation of Physical Evidence.
  8. Midterm Examination.
  9. Identification by DNA and Identification of Missing Persons and Mass Disaster Victim.
  10. Forensic Animal DNA Analysis. Application of DNA- Based Methods in Forensic Entomology.
  11. Forensic Tissue Identification with Nucleic Acids. Evolving Technologies in Forensic DNA Analysis.
  12. Prediction of Physical Characteristics, such as Eye, Hair and Skin Color Based Solely on DNA.
  13. DNA as Evidence in the Courtroom. Some Ethical Issues in Forensic Genetics.
  14. DNA in Immigration and Human Trafficking, DNA Data banking
  15. Final

LABORATORY/PRACTICE PLAN
Week
Topic

    TEACHING/ASSESSMENT
    Description
    • Lectures
    • Presentation
    • Seminar
    • Project
    • Case Studies
    • Demonstration
    Description (%)
    Method Quantity Percentage (%)
    Project120
    Midterm Exam(s)120
    Presentation120
    Final Exam140
    Total: 100
    Learning outcomes
    • Usage all sorts of forensic and genetic analysis methods in processing human, animal and plant biological trace samples.
    • Collecting forensic samples for DNA analysis.
    • Getting experience in all sorts of theoretical knowledge in forensic science based on newest methods of DNA technology and its usage in legal medicine and juridical procedures.
    • Identification based on low-copy DNA samples commonly used for identification of crime perpetrators, mass disaster casualties and paternity testing and understanding techniques currently used in forensic genetics including short tandem repeats (STR) analysis and interpretation, population genetics and mitochondrial and Y chromosome markers.
    • Understanding basic techniques important for creating and usage of National DNA data base and understanding basic biostatistical principles in forensic genetics and introduction of the newest molecular biology techniques used in forensic sciences - understanding of problems in applied forensic genetics and studying reference literature of this field.
    TEXTBOOK(S)
    • Primorac, D., &Schanfield, M. (2014). Forensic DNA Applications: An Interdisciplinary Perspective. Boca Raton: CRC Press.

    ECTS (Allocated based on student) WORKLOAD
    Activities Quantity Duration (Hour) Total Work Load
    Lecture (14 weeks x Lecture hours per week)14342
    Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)14228
    Midterm Examination (1 week)122
    Final Examination(1 week)122
    Preparation for Midterm Examination11515
    Preparation for Final Examination11515
    Assignment / Homework/ Project12525
    Seminar / Presentation12525
    Total Workload: 154
    ECTS Credit (Total workload/25): 6