INTERNATIONAL BURCH UNIVERSITY
Graduate Study - Faculty of Engineering and Natural Sciences
Genetics and Bioengineering PhD
2012-2013

SYLLABUS
Code Name Level Year Semester
GBE 616 Biological Signal Transduction Graduate 1 Spring
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
7.5 135 English

Instructor Assistant Coordinator
Lada Lukić-Bilela, Assist. Prof. Dr. Mehmet Serdal Sakçali, Assoc. Prof. Dr.
[email protected] no email

COURSE OBJECTIVE
A Primary Course Objective:
The course will introduce students to a variety of signal transduction pathways and their function in the regulation of cellular processes. Special emphasis will be given to signaling cascades regulating immunological responses and alterations of signaling pathways during oncogenesis.

COURSE CONTENT
Week
Topic
  1.  Welcome & Introduction to the Course; Introduction to syllabus
  2.  Introduction to Signaling and Cell Comunication
  3.  Structure and Function of Kinases and other Signaling proteins
  4.  Tyrosine Kinase Signaling
  5.  GTP Signal Transduction
  6.  Steroid Signal Transduction
  7.  TGFb/BMP Signaling
  8.  Hedgehog Signaling
  9.  Notch Signaling
  10.  DNA Replication
  11.  Damage and Repair
  12.  Transcriptional Mechanisms in Control of the Cell Cycle
  13.  Tumor suppressors/cell cycle
  14.  Evolution of Signal Mechanisms

LABORATORY/PRACTICE PLAN
Week
Topic

    TEACHING/ASSESSMENT
    Description
    • Lectures
    • Presentation
    • Project
    • Other:1. Interactive lectures and communications with students 2. Discussion and group works
    Description (%)
    Method Quantity Percentage (%)
    Homework5
    Project10
    Midterm Exam(s)30
    Presentation5
    Final Exam140
    +Actively Participation 10 %
    Total: 90
    Learning outcomes
    • Signal Transduction
    • Cell Comunication
    • Membrane Receptors
    • Cell Cycle Regulation
    • Gene Transcription
    TEXTBOOK(S)
    • Required
    • 1. Sitaramayya Ari (ed.) (2010). Signal Transduction: Pathways, Mechanisms and Diseases. Springer Heidelberg Dordrecht, London, New York.
    • 2. Pickens, Charles O. (ed.) Cell Apoptotic Signalling Pathways. Nova Science Publishers, Inc; Hauppauge NY.

    ECTS (Allocated based on student) WORKLOAD
    Activities Quantity Duration (Hour) Total Work Load
    Lecture (14 weeks x Lecture hours per week)453135
    Laboratory / Practice (14 weeks x Laboratory/Practice hours per week) 0
    Midterm Examination (1 week)1 0
    Final Examination(1 week)1 0
    Preparation for Midterm Examination 0
    Preparation for Final Examination7.50
    Total Workload: 135
    ECTS Credit (Total workload/25): 5