INTERNATIONAL BURCH UNIVERSITY
Graduate Study - Faculty of Engineering and Natural Sciences
Genetics and Bioengineering PhD
2014-2015

SYLLABUS
Code Name Level Year Semester
GBE 612 Functional Genomics Graduate 1 Fall
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
Area Elective 6 3 118 English

Instructor Assistant Coordinator
Lada Lukić Bilela, Assoc. Prof. Dr. - Lada Lukić-Bilela, Assist. Prof. Dr.
[email protected] - no email

Functional genomics focuses on the dynamic aspects such as gene transcription, translation, and protein–protein interactions, as opposed to the static aspects of the genomic information such as DNA sequence or structures.

COURSE OBJECTIVE
Understanding the relationship between an organism’s genome and its phenotype.

COURSE CONTENT
Week
Topic
  1. Genome Architecture
  2. Functional vs. Comparative Genomics
  3. Genome Mapping and Organization
  4. Genome Sequencing Projects
  5. Assembling Genome Sequences
  6. Sequence Polymorphisms in Genomes and SNPs
  7. Differential Display, Gene Discovery – Expressed Sequence Tags (ESTs)
  8. Serial Analysis of Gene Expression (SAGE)
  9. cDNA Microarrays, Oligonucleotide Microarrays, Regulation of Gene Expression
  10. Protein–protein interactions: Yeast two-hybrid system; AP/MS
  11. Site-directed Mutagenesis
  12. Forward and Reverse Genetics
  13. RNAi-mediated Gene Silencing, Gene Knockouts, Micro-RNAs and Small RNAs
  14. Metabolomics
  15. Application of Functional Genomics in Medicine, Forensic, Agriculture and Population Studies

LABORATORY/PRACTICE PLAN
Week
Topic

    TEACHING/ASSESSMENT
    Description
    • Lectures
    • Presentation
    • Project
    • Case Studies
    Description (%)
    Method Quantity Percentage (%)
    Homework15
    Project115
    Midterm Exam(s)130
    Final Exam140
    +Actively participation110
    Total: 100
    Learning outcomes
    • Critical Thinking and Quantitative Reasoning in GBE
    • Genetic and Bioengineering Application
    • Genetic and Bioengineering Management
    • Genetic and Bioengineering Professional Practice
    • Genetic and Bioengineering Systems and Theory Practice
    TEXTBOOK(S)
    • 1. Pevsner, Jonathan (2009) Bioinformatics and Functional Genomics. 2nd edition, Wiley- Blackwell, 2009, New Jersey, USA.
    • 2. Functional Genomics (Methods in Molecular Biology), Humana Press, Softcover reprint of hardcover 1st ed. 2003. (dec. 9, 2010).

    ECTS (Allocated based on student) WORKLOAD
    Activities Quantity Duration (Hour) Total Work Load
    Lecture (14 weeks x Lecture hours per week)14342
    Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)14342
    Midterm Examination (1 week)122
    Final Examination(1 week)122
    Preparation for Midterm Examination11515
    Preparation for Final Examination11515
    Assignment / Homework/ Project 300
    Seminar / Presentation 300
    Total Workload: 118
    ECTS Credit (Total workload/25): 5