INTERNATIONAL BURCH UNIVERSITY
Graduate Study - Faculty of Engineering and Natural Sciences
Genetics and Bioengineering PhD
2014-2015

SYLLABUS
Code Name Level Year Semester
GBE 609 Biological Signal Transduction Graduate 1 Spring
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
6 188 English

Instructor Assistant Coordinator
Lada Lukić Bilela, Assoc. Prof. Dr. - Lada Lukić Bilela, Assoc. Prof. Dr.
[email protected] - no email

The course will introduce students to a variety of signal transduction pathways and their function in the regulation of cellular processes. Special emphasis will be given to signaling cascades regulating immunological responses and alterations of signaling pathways during oncogenesis.

COURSE OBJECTIVE
General Course Objectives:
Upon completion of this course, the student will be familiar with:
 signal transduction
 membrane receptors
 second messengers
 cell cycle regulation
 gene transcription
 cancer biology
 mammalian development
 endocrine and neurohumoral signaling

COURSE CONTENT
Week
Topic
  1. Indroduction to Biological Signal Trandsduction
  2. Mechanisms of Cell Communication
  3. Protein Kinases-Structure and Function
  4. New Cancer Therapies Based on Thyrosine Kinase Inhibitors
  5. G Protein-Coupled Receptors
  6. Pathways activated by seven transmembrane receptors and G-proteins, insulin/PI3 kinase, nitric oxide and WNTs and mechanisms of signal termination
  7. Cytokine/Jak/Stat Signaling
  8. Hormone Receptor Interaction
  9. Hedgehog Signalling Pathway
  10. TGF pathway
  11. Genomic Gene Regulation
  12. Regulation of Cell Division
  13. Global Regulators of Cell Cycle Progression
  14. Regulation of p53
  15. Rb and Cell Cycle

LABORATORY/PRACTICE PLAN
Week
Topic

    TEACHING/ASSESSMENT
    Description
    • Lectures
    • Practical Sessions
    • Presentation
    • Project
    • Assignments
    • Case Studies
    Description (%)
    Method Quantity Percentage (%)
    Homework15
    Project115
    Midterm Exam(s)130
    Presentation
    Final Exam140
    +Active Participation110
    Total: 100
    Learning outcomes
    • Learn the basic molecular pathways
    • Learn how signal transduction occurs
    • Learn about molecule-molecule interactions
    • Have information about various pathways
    • Learn the chemistry of signaling
    TEXTBOOK(S)
    • Gomperts, B. D., Kramer, I. M., &Tatham, P. E. R. (2009). Signal Transduction, 2nd ed. Waltham: Academic Press.
    • Sitaramayya Ari (ed.) (2010). Signal Transduction: Pathways, Mechanisms and Diseases. Springer Heidelberg Dordrecht, London, New York.
    • Pickens, Charles O. (ed.) Cell Apoptotic Signalling Pathways. Nova Science Publishers, Inc; Hauppauge NY.

    ECTS (Allocated based on student) WORKLOAD
    Activities Quantity Duration (Hour) Total Work Load
    Lecture (14 weeks x Lecture hours per week)14342
    Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)14342
    Midterm Examination (1 week)122
    Final Examination(1 week)122
    Preparation for Midterm Examination11515
    Preparation for Final Examination12525
    Assignment / Homework/ Project13030
    Seminar / Presentation13030
    Total Workload: 188
    ECTS Credit (Total workload/25): 8