INTERNATIONAL BURCH UNIVERSITY
Graduate Study - Faculty of Engineering and Natural Sciences
Genetics and Bioengineering Master With Thesis
2013-2014

SYLLABUS
Code Name Level Year Semester
GBE 526 CANCER BIOLOGY Graduate 1 Fall
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
7.5 121 English

Instructor Assistant Coordinator
, Mehmet Serdal Sak├žali, Assoc. Prof. Dr.
no email no email

COURSE OBJECTIVE
The curriculum is designed to impart a greater understanding of the molecular events that lead to cancer initiation and progression.

COURSE CONTENT
Week
Topic
  1. Genetic, cellular and molecular concepts/Techniques; Basic aspects about cancer
  2. Carcinogens/Tumor viruses; Multi-step carcinogenesis/Angiogenesis
  3. Invasion and Metastasis; Oncogenes; Growth factors and receptors
  4. Tumor suppressor genes
  5. CDK regulation by Cyclin binding/phosphorylation; CDK regulation by CDK inhibitors/RB and E2Fs
  6. Midterm exam
  7. Cell death signaling and cancer; Cellular signaling and cancer
  8. Cell immortalization & tumorigenesis; DNA repair defects can lead to cancers
  9. Cell transformation requires multiple genes; Prevention, early detection & genetic testing for cancer risk; Surgery/radiation therapy/chemotherapy
  10. The rational of treatment of cancer; Presentations
  11. Tumor immunology and immunotherapy; Yeast & fruit fly models of human cancer; Mouse model of human cancer/Delivery of medicine to tumors
  12. Final exam

LABORATORY/PRACTICE PLAN
Week
Topic

    TEACHING/ASSESSMENT
    Description
    • Lectures
    • Presentation
    • Seminar
    • Assignments
    • Case Studies
    • Demonstration
    Description (%)
    Method Quantity Percentage (%)
    Midterm Exam(s)130
    Presentation120
    Final Exam140
    +Attendance
    1
    10%
    Total: 90
    Learning outcomes
    • Chromosome instability
    • Properties of cancer cells and tissues
    • The role of viruses in cancer
    • Tumor suppressor genes/Oncogenes
    • DNA damaging agents
    TEXTBOOK(S)
    • The Biology of Cancer, 1st edition, Robert A. Weinberg, Garland Science

    ECTS (Allocated based on student) WORKLOAD
    Activities Quantity Duration (Hour) Total Work Load
    Lecture (14 weeks x Lecture hours per week)16348
    Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)16348
    Midterm Examination (1 week)11010
    Final Examination(1 week)11515
    Preparation for Midterm Examination 0
    Preparation for Final Examination7.50
    Total Workload: 121
    ECTS Credit (Total workload/25): 5