INTERNATIONAL BURCH UNIVERSITY
Graduate Study - Faculty of Engineering and Natural Sciences
3+2 Genetics and Bioengineering
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||Class Hours Per Week
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|Amina Kurtović Kozarić, Assoc. Prof. Dr.
||Amina Kurtovic Kozaric
||Amina Kurtović Kozarić, Assoc. Prof. Dr.
|This course gives graduate students an advanced level of knowledge in cancer biology by explaining cancer formation and spreading from both molecular and cellular points of view. The first part of the course introduces concepts of cancer, tumor, oncogenes, tumor suppressor genes, and the steps in carcinogenesis. Following this introductory part, the course introduces mutations and defects in DNA that might lead to cancer, as well as the most likely points in cell cycle in which cancer usually develops. The final topics thought in the course are related to cancer diagnosis and treatments. During the course, graduates are expected to read high quality scientific articles and give a short presentation in front of the class in order to show their understanding of the topic.
|The cognitive, affective and behavioral objectives of this course are following:
• Introduction to the fundamental concepts of cancer development.
• Explaining the molecular and genetic basis of cancer.
• Teaching about prevention, detection and treatment of cancer.
- Genetic, cellular, and molecular concepts of cancer development. Techniques. Cancer principles
- Carcinogens. Tumor viruses
- Multi-step carcinogenesis. Angiogenesis
- Invasion and metastasis. Oncogenes
- Growth factors and receptors. Tumor suppressor genes
- CDK regulation by cyclin binding/phosphorylation. CDK regulation by CDK inhibitors/RB and E2Fs
- Cell death signaling and cancer. Cellular signaling and cancer
- MID-TERM EXAM
- Cell immortalization and tumorigenesis
- DNA repair defects can lead to cancers
- Cell transformation requires multiple genes
- Prevention, early detection, and genetic testing for cancer risk
- Surgery, radiation therapy, and chemotherapy
- The rational of treatment of cancer. Tumor immunology and immunotherapy
- Yeast and fruit fly models of human cancer. Mouse model of human cancer. Delivery of medicine to tumors
- Interactive Lectures
| Final Exam||1||40|
- Explain chromosome instability
- Demonstrate the properties of cancer cells and tissues
- Interpret the role of viruses in cancer
- Review the concept of tumor suppressor genes/oncogenes
- Clarify DNA damaging agents/DNA repair
- Weinberg, R. (2013). The biology of cancer. London: Garland Science.
|ECTS (Allocated based on student) WORKLOAD
|Lecture (14 weeks x Lecture hours per week)||15||3||45|
|Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)||15||2||30|
|Midterm Examination (1 week)||1||2||2|
|Final Examination(1 week)||1||2||2|
|Preparation for Midterm Examination||1||10||10|
|Preparation for Final Examination||1||20||20|
|Assignment / Homework/ Project||1||21||21|
|Seminar / Presentation||1||20||20|