INTERNATIONAL BURCH UNIVERSITY
Graduate Study - Faculty of Engineering and Natural Sciences
Genetics and Bioengineering Master With Thesis
2016-2017

SYLLABUS
Code Name Level Year Semester
GBE 515 Cancer Biology Graduate 1 Fall
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
Area Elective 6 3 150 English

Instructor Assistant Coordinator
Amina Kurtović Kozarić, Assoc. Prof. Dr. Amina Kurtovic Kozaric Amina Kurtović Kozarić, Assoc. Prof. Dr.
[email protected] [email protected] no email

This course gives graduate students an advanced level of knowledge in cancer biology by explaining cancer formation and spreading from both molecular and cellular points of view. The first part of the course introduces concepts of cancer, tumor, oncogenes, tumor suppressor genes, and the steps in carcinogenesis. Following this introductory part, the course introduces mutations and defects in DNA that might lead to cancer, as well as the most likely points in cell cycle in which cancer usually develops. The final topics thought in the course are related to cancer diagnosis and treatments. During the course, graduates are expected to read high quality scientific articles and give a short presentation in front of the class in order to show their understanding of the topic.

COURSE OBJECTIVE
The cognitive, affective and behavioral objectives of this course are following:
• Introduction to the fundamental concepts of cancer development.
• Explaining the molecular and genetic basis of cancer.
• Teaching about prevention, detection and treatment of cancer.

COURSE CONTENT
Week
Topic
  1. Genetic, cellular, and molecular concepts of cancer development. Techniques. Cancer principles
  2. Carcinogens. Tumor viruses
  3. Multi-step carcinogenesis. Angiogenesis
  4. Invasion and metastasis. Oncogenes
  5. Growth factors and receptors. Tumor suppressor genes
  6. CDK regulation by cyclin binding/phosphorylation. CDK regulation by CDK inhibitors/RB and E2Fs
  7. Cell death signaling and cancer. Cellular signaling and cancer
  8. MID-TERM EXAM
  9. Cell immortalization and tumorigenesis
  10. DNA repair defects can lead to cancers
  11. Cell transformation requires multiple genes
  12. Prevention, early detection, and genetic testing for cancer risk
  13. Surgery, radiation therapy, and chemotherapy
  14. The rational of treatment of cancer. Tumor immunology and immunotherapy
  15. Yeast and fruit fly models of human cancer. Mouse model of human cancer. Delivery of medicine to tumors

LABORATORY/PRACTICE PLAN
Week
Topic

    TEACHING/ASSESSMENT
    Description
    • Interactive Lectures
    • Presentation
    Description (%)
    Method Quantity Percentage (%)
    Midterm Exam(s)130
    Presentation130
    Final Exam140
    Total: 100
    Learning outcomes
    • Explain chromosome instability
    • Demonstrate the properties of cancer cells and tissues
    • Interpret the role of viruses in cancer
    • Review the concept of tumor suppressor genes/oncogenes
    • Clarify DNA damaging agents/DNA repair
    TEXTBOOK(S)
    • Weinberg, R. (2013). The biology of cancer. London: Garland Science.

    ECTS (Allocated based on student) WORKLOAD
    Activities Quantity Duration (Hour) Total Work Load
    Lecture (14 weeks x Lecture hours per week)15345
    Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)15230
    Midterm Examination (1 week)122
    Final Examination(1 week)122
    Preparation for Midterm Examination11010
    Preparation for Final Examination12020
    Assignment / Homework/ Project12121
    Seminar / Presentation12020
    Total Workload: 150
    ECTS Credit (Total workload/25): 6