INTERNATIONAL BURCH UNIVERSITY
Faculty of Engineering and Natural Sciences
Department of Genetics and Bioengineering
2015-2016

SYLLABUS
Code Name Level Year Semester
GBE 329 Population Genetics Undergraduate 3 Spring
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
Area Elective 5 2 + 2 125 English

Instructor Assistant Coordinator
Serkan DOĞAN, Assist. Prof. Dr. Assist. Prof. Serkan Dogan Lejla Smajlović Skenderagić, Assist. Prof. Dr.
[email protected] [email protected] no email

This course is designed to provide students with a general introduction to population genetics, which examines the interaction of basic evolutionary processes (including mutation, natural selection, genetic drift, inbreeding, recombination, and gene flow) in determining the genetic composition and evolutionary trajectories of natural populations. Methods of measuring genetic variation in natural populations will also be reviewed and experimental tests of the central concepts derived from population genetics theory will be examined. Empirical examples will involve a broad diversity of organisms, including humans.

COURSE OBJECTIVE
 Teaching students the principles of Hardy-Weinberg equilibrium.
 Explaining factors that can affect Hardy-Weinberg equilibrium, such as mutation, inbreeding, migration, and genetic drift.
 Giving an overview of phylogenetic analyses, their possibilities but also limitations and the evolutionary significance of “short-term” and “long-term” adaptation processes.
 Explaining basic concepts about the biological, bio-cultural and socio-cultural characteristics of various human groups and their interpopulation variability as an adaptation response to the impact of environmental factors.
 Providing models of studying contemporary human populations and theoretical evaluations of the impact of genetic and/or ecological factors in terms of phenotype expression of complex features by an array of comparative analyses.

COURSE CONTENT
Week
Topic
  1. Introduction to population genetics and the basic principles
  2. Allele and genotype frequencies; Hardy-Weinberg equilibrium
  3. Allele and genotype frequencies; Hardy-Weinberg equilibrium
  4. Genetic drift and mutation
  5. Population structure and gene flow
  6. Inferring population history and demography
  7. Linkage disequilibrium and gene mapping
  8. MID-TERM EXAM WEEK
  9. Genetic markers in population genetic studies
  10. Population genetics of quantitative traits
  11. Interaction of genotype and surrounding
  12. Heritability: Definition and methods of study
  13. Adaptation and speciation
  14. Phylogenetic variation
  15. Conservation of genetic variation

LABORATORY/PRACTICE PLAN
Week
Topic
  1. Beginning of classes

  1. Introduction to the lab course
  2. Introduction to managing allele frequencies: Mendelian and non-Mendelian inheritance patterns, Human pedigree analysis
  3. Allele and genotype frequencies, Hardy-Weinberg principle, part 1
  4. Allele and genotype frequencies, Hardy-Weinberg principle, part 2
  5. Factors that disturb the genetic equilibrium and their effect: mutation and natural selection
  6. Factors that disturb the genetic equilibrium and their effect: genetic drift and inbreeding
  7. MIDTERM WEEK
  8. Recombination events and genetic mapping
  9. Genetic markers in population genetic studies, Statistical calculations of population differentiation
  10. Population genetics of quantitative traits: Coalescent theory
  11. Phylogenetic studies in evolution
  12. Phylogenetic variation in humans: NJ and UPGMA methods
  13. Preparation for laboratory exam
  14. Exam from lab course

TEACHING/ASSESSMENT
Description
  • Interactive Lectures
  • Practical Sessions
  • Presentation
  • Discussions and group work
Description (%)
Method Quantity Percentage (%)
Midterm Exam(s)120
Laboratory120
Class Deliverables120
Final Exam140
Total: 100
Learning outcomes
  • Explain the basics of population genetics
  • Calculate the Hardy-Weinberg equilibrium
  • Find the frequency of alleles and genotypes in a population
  • Define genetic markers in population genetics
  • Recall basics of phylogenetics
  • Discuss heritability
TEXTBOOK(S)
  • Nielsen, R. &Slatkin, M. (2013). An Introduction to Population Genetics: Theory and Applications, 1st ed. Sunderland, MA, USA: Sinauer Associates

ECTS (Allocated based on student) WORKLOAD
Activities Quantity Duration (Hour) Total Work Load
Lecture (14 weeks x Lecture hours per week)15230
Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)15230
Midterm Examination (1 week)122
Final Examination(1 week)122
Preparation for Midterm Examination11414
Preparation for Final Examination11515
Assignment / Homework/ Project11414
Seminar / Presentation11818
Total Workload: 125
ECTS Credit (Total workload/25): 5