Faculty of Engineering and Natural Sciences
Department of Genetics and Bioengineering

Code Name Level Year Semester
GBE 329 Population Genetics Undergraduate 3 Fall
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
Area Elective 5 2 + 2 125 English

Instructor Assistant Coordinator
Serkan DOĞAN, Assist. Prof. Dr. Assist. Prof. Serkan Dogan Serkan DOĞAN, Assist. Prof. Dr.
[email protected] [email protected] no email

This course is designed to familiarize you with the field of population genetics, the branch of evolutionary biology concerned with the genetic structure of populations and how it changes through time. Population genetics is the backbone of evolutionary biology due to the changes in the genetic composition of a population are the basis of the most evolutionary changes. Methods of measuring genetic variation in natural populations will also be reviewed and experimental tests of the central concepts derived from population genetics theory will be examined. Empirical examples will involve a broad diversity of organisms, including humans. Mathematics is a good way to abstract a problem, and formalize logical arguments. Consequently, population genetics involves a fair amount of mathematics.

• Teaching students the principles of Hardy-Weinberg equilibrium.
• Explaining factors that can affect Hardy-Weinberg equilibrium, such as mutation, inbreeding, migration, and genetic drift.
• Giving an overview of phylogenetic analyses, their possibilities but also limitations and the evolutionary significance of “short-term” and “long-term” adaptation processes.
• Explaining basic concepts about the biological, bio-cultural and socio-cultural characteristics of various human groups and their interpopulation variability as an adaptation response to the impact of environmental factors.
• Providing models of studying contemporary human populations and theoretical evaluations of the impact of genetic and/or ecological factors in terms of phenotype expression of complex features by an array of comparative analyses.

  1. The scope and background of population genetics
  2. Hardy-Weinberg equilibrium
  3. Extensions of Hardy-Weinberg equilibrium; scientific paper analysis
  4. Inbreeding
  5. Mutation; linkage and recombination; transposable elements
  6. Genetic drift
  7. Gene flow
  8. Midterm exam week
  9. Darwin\'s theory of evolution; natural selection
  10. Practical examples of natural selection; scientific paper analysis
  11. Multilocus and sex-linked traits; evolutionary advantage of sex
  12. Quantitative genetics, part 1
  13. Quantitative genetics, part 2
  14. Phylogeny in population genetics
  15. Human population history and structure

  1. Beginning of classes

  1. Introduction to the lab course
  2. Hardy-Weinberg equilibrium
  3. Extensions of Hardy-Weinberg equilibrium
  4. Inbreeding
  5. Genetic drift
  6. Gene flow
  7. Midterm exam week
  8. Examples of natural selection
  9. Quantitative genetics, part 1
  10. Quantitative genetics, part 2
  11. Phylogeny
  12. Recap
  13. Lab test
  14. Free week

  • Interactive Lectures
  • Excersises
  • Presentation
  • Discussions and group work
  • Problem solving
  • Assignments
  • Case Studies
  • Use of educational films
Description (%)
Method Quantity Percentage (%)
Midterm Exam(s)120
Class Deliverables120
Final Exam140
Total: 100
Learning outcomes
  • Explain the basics of population genetics
  • Calculate the Hardy-Weinberg equilibrium
  • Find the frequency of alleles and genotypes in a population
  • Become familiar with the concepts and calculations of gene flow, genetic drift and inbreeding
  • Recall basics of phylogenetics
  • Discuss mutations and transposable elements
  • Review the processes and influence of natural selection
  • Understand the specific characteristics of human population genetics
  • Relethford, J.H. (2012). Human Population Genetics. Hoboken, NJ: John Wiley & Sons, Inc.

ECTS (Allocated based on student) WORKLOAD
Activities Quantity Duration (Hour) Total Work Load
Lecture (14 weeks x Lecture hours per week)15230
Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)15230
Midterm Examination (1 week)122
Final Examination(1 week)122
Preparation for Midterm Examination11414
Preparation for Final Examination11515
Assignment / Homework/ Project11414
Seminar / Presentation11818
Total Workload: 125
ECTS Credit (Total workload/25): 5