INTERNATIONAL BURCH UNIVERSITY
Faculty of Engineering and Natural Sciences
Department of Genetics and Bioengineering
2016-2017

SYLLABUS
Code Name Level Year Semester
GBE 329 Population Genetics Undergraduate 3 Fall
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
Area Elective 5 2 + 2 125 English

Instructor Assistant Coordinator
Serkan DOĞAN, Assist. Prof. Dr. Assist. Prof. Serkan Dogan Serkan DOĞAN, Assist. Prof. Dr.
[email protected] [email protected] no email

This course is designed to familiarize you with the field of population genetics, the branch of evolutionary biology concerned with the genetic structure of populations and how it changes through time. Population genetics is the backbone of evolutionary biology due to the changes in the genetic composition of a population are the basis of the most evolutionary changes. Methods of measuring genetic variation in natural populations will also be reviewed and experimental tests of the central concepts derived from population genetics theory will be examined. Empirical examples will involve a broad diversity of organisms, including humans. Mathematics is a good way to abstract a problem, and formalize logical arguments. Consequently, population genetics involves a fair amount of mathematics.

COURSE OBJECTIVE
• Teaching students the principles of Hardy-Weinberg equilibrium.
• Explaining factors that can affect Hardy-Weinberg equilibrium, such as mutation, inbreeding, migration, and genetic drift.
• Giving an overview of phylogenetic analyses, their possibilities but also limitations and the evolutionary significance of “short-term” and “long-term” adaptation processes.
• Explaining basic concepts about the biological, bio-cultural and socio-cultural characteristics of various human groups and their interpopulation variability as an adaptation response to the impact of environmental factors.
• Providing models of studying contemporary human populations and theoretical evaluations of the impact of genetic and/or ecological factors in terms of phenotype expression of complex features by an array of comparative analyses.

COURSE CONTENT
Week
Topic
  1. Introduction to population genetics and the basic principles
  2. Allele and genotype frequencies; Hardy-Weinberg equilibrium
  3. Genetic variation, sources of genetic variation and inbreeding
  4. Genetic drift and mutation
  5. Population structure and gene flow
  6. Inferring population history and demography
  7. Linkage disequilibrium and gene mapping
  8. Fundamentals of natural selection
  9. MID-TERM EXAM WEEK
  10. Genetic markers in population genetic studies
  11. Genetic markers in population genetic studies
  12. Population genetics of quantitative traits
  13. Interaction of genotype and surrounding
  14. Phylogenetic variation
  15. Conservation of genetic variation

LABORATORY/PRACTICE PLAN
Week
Topic
  1. Beginning of classes

  1. Introduction to the lab course/Data collection
  2. Data management and seminar paper introduction
  3. Allele and genotype frequencies, Hardy-Weinberg principle
  4. Inbreeding
  5. Genetic drift part: I
  6. Genetic drift part: II Computer Simulation
  7. MID-TERM EXAM WEEK
  8. Natural selection
  9. Mutations
  10. Genetic markers
  11. Calculating heritability
  12. Creating a phylogenetic tree
  13. Seminar paper presentations
  14. FINAL EXAM WEEK

TEACHING/ASSESSMENT
Description
  • Interactive Lectures
  • Practical Sessions
  • Presentation
  • Discussions and group work
Description (%)
Method Quantity Percentage (%)
Midterm Exam(s)120
Laboratory120
Class Deliverables120
Final Exam140
Total: 100
Learning outcomes
  • Explain the basics of population genetics
  • Calculate the Hardy-Weinberg equilibrium
  • Find the frequency of alleles and genotypes in a population
  • Define genetic markers in population genetics
  • Recall basics of phylogenetics
  • Discuss heritability
TEXTBOOK(S)

    ECTS (Allocated based on student) WORKLOAD
    Activities Quantity Duration (Hour) Total Work Load
    Lecture (14 weeks x Lecture hours per week)15230
    Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)15230
    Midterm Examination (1 week)122
    Final Examination(1 week)122
    Preparation for Midterm Examination11414
    Preparation for Final Examination11515
    Assignment / Homework/ Project11414
    Seminar / Presentation11818
    Total Workload: 125
    ECTS Credit (Total workload/25): 5