INTERNATIONAL BURCH UNIVERSITY
Faculty of Engineering and Natural Sciences
Department of Genetics and Bioengineering
2014-2015

SYLLABUS
Code Name Level Year Semester
GBE 328 Human Genetics Undergraduate 3 Fall
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
5 89 English

Instructor Assistant Coordinator
Damir Marjanović, Prof. Dr. Damir Marjanović, Prof. Dr.
[email protected] no email

COURSE OBJECTIVE
This course focuses on the role of genes in human biology and society. Selected areas of emphasis range from gene structure and identification, to inheritance mechanisms (how genes are passed from parent to offspring), and how genes work within the cellular environment, to what can go wrong with genes (mutations) and the consequences of these malfunctions (genetic diseases), to the genetic structure of whole populations, and finally to ethical, legal, and social issues surrounding the application of the new genetic engineering and reproductive technologies. We will cover the three basic areas of modern genetics (molecular genetics, transmission genetics, population genetics), but focus primarily on humans. Another important goal of the course is to not only achieve an understanding of the Scientific Method, but also to apply it throughout the semester.

COURSE CONTENT
Week
Topic
  1. The basics of human genetics (structure and function of the human genome),
  2. The mechanisms involved in genetic variation at the level of the gene and gene product, mutagenesis and the DNA repair, mutations as a cause of genetic disorders
  3. Human Genome Project
  4. Pedigree analysis, linkage analysis, gene mapping
  5. The basic principles of inheritance - mendelian and non-mendelian (UDP, dynamic mutations, mosaicism, imprinting) forms of inheritance, multifactorial inheritance, interaction of genes and environmental factors
  6. Laboratory methods of DNA (DNA typing/profiling, RFLP, PCR, STR, mtDNA and Y chromosome analysis) and chromosome (karyotyping and FISH) analysis in human genetic practice
  7. Introduction to the gene therapy
  8. Interpretation and application of various human genetic tests
  9. Introduction to the human population genetics
  10. The ethical, legal and social aspects of human genetic testing

LABORATORY/PRACTICE PLAN
Week
Topic
  1. INTRODUCTION TO GOOD LABORATORY PRACTICE
  2. HUMAN MITOSIS AND MEIOSIS
  3. CHROMOSOMES IN CELLS -VISUALISATION
  4. KARYOGRAM ASSEMBLY

  1. DOMINANT AND RECESSIVE INHERITANCE IN HUMANS
  2. GENES IN PEDIGREES
  3. MENDELIAN TRAITS PART I
  4. MENDELIAN TRAITS PART II
  5. CHI SQUARE METHOD
  6. POPULATION GENETICS
  7. HUMAN DNA ISOLATION FROM BUCCAL MUCOSA
  8. HUMAN DNA ISOLATION FROM BLOOD
  9. HUMAN DNA ISOLATION FROM HAIR, BONES AND OTHER TISSUES
  10. SUMMARY

TEACHING/ASSESSMENT
Description
  • Lectures
  • Practical Sessions
  • Presentation
  • Seminar
  • Self Evaluation
  • Assignments
Description (%)
Method Quantity Percentage (%)
Quiz20
Project20
Midterm Exam(s)20
Final Exam140
Total: 100
Learning outcomes
  • Actively participate in courses and begin to take responsibility for learning
  • Begin to work effectively as part of a team, developing interpersonal, organizational, and problem-solving skills within a managed environment, exercising some personal responsibility
  • Present information in oral, written or graphic forms in order to communicate effectively with peers and tutors
TEXTBOOK(S)
  • • Lewis, R. (2008). Human Genetics: Concepts and Applications, 8th ed. McGraw-Hill:New York, NY, USA
  • • Peter Sudbery, Ian Sudbery (2010). Human and Molecular Genetics. 3rd edition Publisher: Pearson Education Ltd.
  • • Current scientific literature

ECTS (Allocated based on student) WORKLOAD
Activities Quantity Duration (Hour) Total Work Load
Lecture (14 weeks x Lecture hours per week)14228
Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)14228
Midterm Examination (1 week)122
Final Examination(1 week)122
Preparation for Midterm Examination11414
Preparation for Final Examination11515
Assignment / Homework/ Project 180
Seminar / Presentation 180
Total Workload: 89
ECTS Credit (Total workload/25): 4