INTERNATIONAL BURCH UNIVERSITY
Faculty of Engineering and Natural Sciences
Department of Genetics and Bioengineering
||Number of ECTS Credits
||Class Hours Per Week
||Total Hours Per Semester
|Lejla Smajlović Skenderagić, Assist. Prof. Dr.
||Assist. Prof. Dr. Lejla Smajlovic Skenderagic
||Lejla Smajlović Skenderagić, Assist. Prof. Dr.
|This lecture and laboratory course will focus on human chromosome structure and replication, methodology, form and function, identification and techniques for the visualization of chromosome aberrations. The latter part of the semester focuses on evolution and speciation, sex chromosome systems, artificial manipulation of genomes as well as the human karyotype. Chromosome abnormalities will be discussed from the clinical and cytogenetic viewpoint. The course will also cover current topics in cytogenetics, including new methodologies and their use in clinical genetics and research. Laboratory course covers both experimental techniques in cytogenetics, as well as detailed study of human chromosomes through virtual labs and recitations.
|The cognitive, affective and behavioral objectives of this course are following:
• Introduction to chromosomes, their structure and function.
• Introduction to the cell cycle.
• Preparation of chromosomes for observations.
• Explaining mutations and aberrations.
• Explaining human karyotype.
- Introduction to cytogenetics
- Chromosome structure and replication
- Chromosome form and function
- Chromosome identification
- Nuclear division
- Gene control by position and origin
- MIDTERM EXAM
- Chromosome mapping
- Sex chromosome systems
- Evolution and speciation
- Artificial manipulation of genomes
- The human karyotype
- Chromosomal aberrations and their identification
- Historical aspects of cytogenetics
- Beginning of classes
- Introduction to lab course
- Cell Cycle: Interphase, mitosis, and meiosis
- Techniques of making chromosome slides
- Chromosome staining techniques, part 1
- Chromosome staining techniques, part 2
- Getting and marking cells in prophase or prometaphase
- MID-TERM EXAM WEEK
- Study of sex chromatin
- Microscopic observations and microphotography
- Nomenclature and chromosome classification
- Preparing a karyotype
- Common chromosomal abnormalities
- Preparation for practical exam
- Practical exam from lab course
- Interactive Lectures
- Practical Sessions
- Discussions and group work
| Lab/Practical Exam(s)||1||20|
| Final Exam||1||40|
| +Seminar & Assignement ||1 ||20|
- Students should be able to describe the cell cycle
- Students should be able to classify chromosomal banding and its application
- Students should be able to determine structural and numerical chromosomal aberrations
- Students should be able to explain the nomenclature of chromosomes
- Students should be able to analyze karyotipe
- Clark, M.S., Wall, W.J., (1996) Chromosomes: The complex code, Chapman & Hall
|ECTS (Allocated based on student) WORKLOAD
|Lecture (14 weeks x Lecture hours per week)||15||2||30|
|Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)||15||2||30|
|Midterm Examination (1 week)||1||2||2|
|Final Examination(1 week)||1||2||2|
|Preparation for Midterm Examination||1||14||14|
|Preparation for Final Examination||1||15||15|
|Assignment / Homework/ Project||1||14||14|
|Seminar / Presentation||1||18||18|