Faculty of Engineering and Natural Sciences
Department of Genetics and Bioengineering

Code Name Level Year Semester
GBE 320 Systems Physiology Undergraduate 2 Spring
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
Area Elective 5 2 + 2 125 English

Instructor Assistant Coordinator
Lejla Smajlović Skenderagić, Assist. Prof. Dr. Asist. Prof. Dr. Lejla Smajlovic Skenderagic Lejla Smajlović Skenderagić, Assist. Prof. Dr.
[email protected] [email protected] no email

The course offers an overview of the functioning systems of the human body. The physiology of cells as well as the muscular,nervous, circulatory, respiratory, endocrine, digestive, and urogenital systems is explored. Emphasis is placed on the integration of the individual function of different cells and organ systems into a functional whole, the feedback mechanisms that account for necessary balances, and the consequences of disease. Examples of engineering approaches used to monitor physiological processes and correct physiological deficiencies are included. The course is taken concurrently with laboratory sessions, which are organized as either experiments or virtual labs.

The cognitive, affective and behavioural objectives of this course are following:
- Introduction to metabolic pathways commonly used by cells and explaining how enzymes function in those pathways.
- Explaining how neurons communicate with each other and with other cells, such as muscles and glands.
- Providing basic concepts of blood and how it circulates in the body.
- Describing how the body defends itself against foreign invaders.
- Teaching the respiratory system function including breathing and gas exchange in the lungs and body tissues.
- Explaining how the digestive system mechanically and chemically breaks food down for absorption.
- Giving an overview of urine formation and its hormonal control.
- Explaining the difference between reproductive processes that occur in males and those that occur in females.

  1. Introduction to Systems Physiology
  2. Basis of animal function and cell physiology, Membranes and movement across the membrane
  3. Homeostasis: Mechanisms and signal transduction
  4. Endocrine system: Endocrine communication and principles of hormonal systems
  5. Autonomic nervous system: Neural communication and mechanisms
  6. Neurophysiology: sensory systems, vision, audition, vestibular system, olfaction, taste
  7. Muscular system: Muscle contraction and the control of body movement
  8. Mid-term Exam
  9. Cardiovascular system: Circulation and the design of cardiovascular system
  10. Respiratory system: System mechanics, gas transport and control of respiration
  11. Urinary system: Kidney, clearance, and the countercurrent mechanism
  12. Digestive system: Gastrointestinal motility, secretion, digestion, and absorption
  13. Immune system: Integration, temperature, food intake, immunity, and exercise
  14. Reproductive system: From sex differentiation to adult reproduction
  15. Integumentary system

    1. Beginning of Classes
    2. Introduction to System Physiology; Lab and Safety Rules
    3. Osmosis and difussion lab
    4. Endocrine System- Virtual Lab
    5. Nervous system – virtual lab
    6. Neurophysiology – virtual lab
    7. Muscular system - virtual lab
    8. Midterm exam week
    9. Cardiovascular system - virtual lab (Salmo trutta fario)
    10. Respiratory system – virtual lab
    11. Urinary system - virtual lab (Urine analysis)
    12. Digestive system – virtual lab
    13. Male and female reproductive system – virtual lab
    14. Preparation for practical exam
    15. Final Lab Exam

    • Interactive Lectures
    • Practical Sessions
    • Presentation
    • Discussions and group work
    • Problem solving
    • Assignments
    • Case Studies
    Description (%)
    Method Quantity Percentage (%)
    Midterm Exam(s)120
    Final Exam140
    +Seminar & Assigment 1 20
    Total: 100
    Learning outcomes
    • Students should be able to Review the basics of physiology of different organ system
    • Students should be able to Connect the structure and function of various systems
    • Students should be able to Explain the concept of experimental animals
    • Students should be able to Perform animal experiments in a bioethical manner
    • Students should be able to Operate animal dissection safely and efficiently
    • Linda S. Constanzo (2014), Physiology, Fifth edition, Saunders, Elsevier

    ECTS (Allocated based on student) WORKLOAD
    Activities Quantity Duration (Hour) Total Work Load
    Lecture (14 weeks x Lecture hours per week)15230
    Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)15230
    Midterm Examination (1 week)122
    Final Examination(1 week)122
    Preparation for Midterm Examination11414
    Preparation for Final Examination11515
    Assignment / Homework/ Project11616
    Seminar / Presentation11616
    Total Workload: 125
    ECTS Credit (Total workload/25): 5