Faculty of Engineering and Natural Sciences
Department of Genetics and Bioengineering

Code Name Level Year Semester
GBE 320 Systems Physiology Undergraduate 2 Spring
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
Area Elective 5 2 + 2 125 English

Instructor Assistant Coordinator
Serkan DOĞAN, Assist. Prof. Dr. Asist. Prof. Dr. Serkan Dogan Serkan DOĞAN, Assist. Prof. Dr.
[email protected] [email protected] no email

The course offers an overview of the functioning systems of the human body. The physiology of cells as well as the muscular,nervous, circulatory, respiratory, endocrine, digestive, and urogenital systems is explored. Emphasis is placed on the integration of the individual function of different cells and organ systems into a functional whole, the feedback mechanisms that account for necessary balances, and the consequences of disease. Examples of engineering approaches used to monitor physiological processes and correct physiological deficiencies are included. The course is taken concurrently with laboratory sessions, which are organized as either experiments or virtual labs.

The cognitive, affective and behavioural objectives of this course are following:
 Introduction to metabolic pathways commonly used by cells and explaining how enzymes function in those pathways.
 Explaining how neurons communicate with each other and with other cells, such as muscles and glands.
 Providing basic concepts of blood and how it circulates in the body.
 Describing how the body defends itself against foreign invaders.
 Teaching the respiratory system function including breathing and gas exchange in the lungs and body tissues.
 Explaining how the digestive system mechanically and chemically breaks food down for absorption.
 Giving an overview of urine formation and its hormonal control.
 Explaining the difference between reproductive processes that occur in males and those that occur in females.

  1. Introduction to Systems Physiology
  2. Functional Organization of the Human Body and Control of the “Internal Environment” (Chapter I- Guyton and Hall)
  3. Muscle Physiology (Whole Section III- Raff)
  4. Cardiovascular Physiology ( Overview of the Cardiac System, Cardiac Muscle Cells, The Heart Pump- Raff)
  5. Pulmonary physiology (Function and Structure of the Respiratory System, Mechanics of the Respiratory System- Raff)
  6. Renal Physiology (Renal Functions, Basic Processes and Anatomy; Renal Blood Flow and Glomerulal Filtration; Clearance- Raff)
  7. GI Physiology (Overview of the GI System- Fuctional Anatomy and Regulation, Gastric Secretion, Pancreatic and Salivary Secretion, Water and Electrolyte Absorption and Secretion, Intestinal Motility- Raff)
  8. Mid-term Exam
  9. Immune system physiology (Chapters 33, 34 and 35- Guyton and Hall)

  1. Endocrine and Metabolic Physiology ( Whole Section 9- Raff until Reproductive Systems)
  2. Reproductive System Physiology (Male and Female Reproductive Systems- Raff)
  3. CNS- Neural Physiolgy (Introduction to the Nervous System, General Sensory Systems: Touch, Pain and Temperature; Spinal Reflexes- Raff)
  4. CNS- Neural Physiology ( Continued )- Special Senses ( Vision, Hearing and Equilibrium, Smell and Taste)
  5. CNS- Neural Physiology ( Continued ) (Learning, Memory, Lanugage and Speech)
  6. Integrative Phyisiology (Whole section 10- Raff)

  1. Beginning of Classes
  2. Introduction to System Physiology; Lab and Safety Rules
  3. Muscles and Muscle Tissue Dissection using Chicken Wings
  4. The Heart; Blood Pressure and Heart Rate
  5. Respiratory System Mechanics
  6. Microscopic and Chemical Urine Analysis
  7. Chemical Digestion of Nutrients
  8. Midterm exam
  9. Characteristics and Composition of Bile
  10. Immune System Cells –Microscopic Analysis
  11. Endocrine System- Virtual Lab
  12. Learning and Memory- Brain Games
  13. Integumentary System- Skin and Hair Physiology
  14. Summary
  15. Final Lab Exam

  • Interactive Lectures
  • Practical Sessions
  • Presentation
  • Assignments
Description (%)
Method Quantity Percentage (%)
Midterm Exam(s)120
Final Exam140
Total: 100
Learning outcomes
  • Students should be able to Review the basics of physiology of different organ system
  • Students should be able to Connect the structure and function of various systems
  • Students should be able to Explain the concept of experimental animals
  • Students should be able to Perform animal experiments in a bioethical manner
  • Students should be able to Operate animal dissection safely and efficiently
  • 1.Raff, H., & Levitzky, M. (2011). Medical Physiology: A Systems Approach: A Systems Approach. McGraw Hill Professional.
  • 2.Hall, J. E. (2015). Guyton and Hall textbook of medical physiology. Elsevier Health Sciences.

ECTS (Allocated based on student) WORKLOAD
Activities Quantity Duration (Hour) Total Work Load
Lecture (14 weeks x Lecture hours per week)14228
Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)14228
Midterm Examination (1 week)122
Final Examination(1 week)122
Preparation for Midterm Examination11414
Preparation for Final Examination11515
Assignment / Homework/ Project11818
Seminar / Presentation11818
Total Workload: 125
ECTS Credit (Total workload/25): 5