Faculty of Engineering and Natural Sciences
Department of Genetics and Bioengineering

Code Name Level Year Semester
GBE 309 Human Genetics Undergraduate 3 Fall
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
Compulsory 5 2 + 2 125 English

Instructor Assistant Coordinator
Amina Kurtović Kozarić, Assoc. Prof. Dr. Amina Kurtovic Kozaric Amina Kurtović Kozarić, Assoc. Prof. Dr.
[email protected] [email protected] no email

This course will focus on concepts such as organization, structure, function, and mapping of the human genome; biochemical and molecular basis, screening, prevention, and treatment of various human diseases; genetic variation in humans; gene frequencies in human populations; human developmental genetics, medical genetics, and other aspects of human heredity. This course focuses on the role of genes in human biology. Selected areas of emphasis range from gene structure and identification, inheritance mechanisms (how genes are passed from parent to offspring), and how genes work within the cellular environment, mutations and the consequences of these malfunctions (genetic diseases), to the genetic structure of whole populations, and finally to ethical, legal, and social issues surrounding the application of the new genetic engineering technologies. Basic areas of modern genetics will be covered, with an emphasis primarily on humans. This is taken concurrently with a laboratory course.

The cognitive, affective and behavioral objectives of this course are following:
• Explaining the role of genes in human biology.
• Providing the basic concepts of molecular genetics.
• Introduction to population genetics.
• Illustrating how to analyze human pedigrees and how to perform gene mapping.

  1. Introduction to human genetics
  2. The basics of human genetics: Structure and function of the human genome
  3. The mechanisms involved in genetic variation at the level of gene and gene product, mutagenesis and DNA repair, mutations as a cause of genetic disorders
  4. Human Genome Project
  5. Pedigree analysis
  6. Linkage analysis
  7. Gene mapping
  9. The basic principles of inheritance: Mendelian and non-Mendelian genetics (UDP, dynamic mutations, mosaicism, imprinting)
  10. Multifactorial inheritance: Interaction of genes and environmental factors
  11. Laboratory methods of DNA (DNA typing/profiling, RFLP, PCR, STR, mtDNA and Y chromosome analysis) and chromosome (karyotyping and FISH) analysis in human genetic practice
  12. Introduction to gene therapy
  13. Interpretation and application of various human genetic tests
  14. Introduction to human population genetics
  15. Ethical, legal, and social aspects of human genetic testing

  1. Beginning of classes
  2. Introduction
  3. Human pedigree analysis
  4. Human pedigree analysis
  5. Genetic linkage and mapping

  1. Mitochondrial DNA isolation from hair (Chelex method)
  2. Restriction digestion of mtDNA from hair
  4. DNA isolation from buccal swab (Chelex method
  5. Polymerase chain reaction: Theoretical introduction
  6. PCR analysis
  7. Agarose gel electrophoresis of PCR products
  8. Agarose gel of PCR products: Results interpretation
  9. Preparation for practical exam
  10. Practical exam from lab course

  • Interactive Lectures
  • Practical Sessions
  • Presentation
  • Problem solving
  • Assignments
Description (%)
Method Quantity Percentage (%)
Midterm Exam(s)120
Lab/Practical Exam(s)120
Final Exam140
Total: 100
Learning outcomes
  • Perform pedigree analysis
  • Clarify gene mapping
  • Interpret various human genetic tests
  • Perform DNA isolation
  • Illustrate the molecular mechanism of PCR and perform PCR
  • Lewis, R. (2009). Human Genetics: Concepts and Applications, 9th ed. New York, NY, USA: McGraw-Hill

ECTS (Allocated based on student) WORKLOAD
Activities Quantity Duration (Hour) Total Work Load
Lecture (14 weeks x Lecture hours per week)15230
Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)15230
Midterm Examination (1 week)122
Final Examination(1 week)122
Preparation for Midterm Examination11414
Preparation for Final Examination11515
Assignment / Homework/ Project11616
Seminar / Presentation11616
Total Workload: 125
ECTS Credit (Total workload/25): 5