INTERNATIONAL BURCH UNIVERSITY
Faculty of Engineering and Natural Sciences
Department of Genetics and Bioengineering
2015-2016

SYLLABUS
Code Name Level Year Semester
GBE 301 Genetics Undergraduate 3 Fall
Status Number of ECTS Credits Class Hours Per Week Total Hours Per Semester Language
5 149 English

Instructor Assistant Coordinator
Serkan DOĞAN, Assist. Prof. Dr. Serkan Dogan Serkan DOĞAN, Assist. Prof. Dr.
[email protected] [email protected] no email

This course is an overall examination of the basic principles of genetics in eukaryotes and prokaryotes at the level of molecules, cells, as well as multicellular organisms, including Homo sapiens. Topics include Mendelian and nonMendelian inheritance, structure and function of chromosomes and genomes, biological variation resulting from recombination, mutation, and selection, gene expression and environmental effects, and population genetics. This is taken concurrently with a laboratory course.

COURSE OBJECTIVE
The cognitive, affective and behavioral objectives of this course are following:
 Helping students become familiar with the language of genetics.
 Providing students with a strong background in the principles of Mendelian and non-Mendelian models of
inheritance and enabling them to use this knowledge to track alleles through generations, to categorize and
predict genotypes and phenotypes.
 Explaining the Hardy-Weinberg equilibrium equation and the requirements for maintaining Hardy-Weinberg
equilibrium in a population.

COURSE CONTENT
Week
Topic
  1. DNA Structure and DNA Manipulation: DNA Markers; The Terminology of Genetic Analysis
  2. Transmission Genetics: The Principle of Segregation; The Principle of Independent Assortment
  3. Transmission Genetics: Human Pedigree Analysis
  4. Non-Mendelian Genetics; Mutation; Genes and the Environment
  5. The Cell Cycle: Mitosis and Meiosis
  6. Sex-Chromosome Inheritance
  7. Pedigrees and Probability; Probability in the Prediction of Progeny Distributions; Testing Goodness of Fit to a Genetic Hypothesis
  8. MID-TERM EXAM WEEK
  9. Genetic Linkage and Chromosome Mapping
  10. Human Karyotypes and Chromosome Behavior
  11. Genetic Control of Development
  12. Molecular Mechanisms of Mutation and DNA Repair
  13. Molecular Genetics of the Cell Cycle and Cancer
  14. Mitochondrial DNA and Extranuclear Inheritance
  15. Molecular Evolution and Population Genetics

LABORATORY/PRACTICE PLAN
Week
Topic
  1. Beginning of classes
  2. Introduction

  1. Introduction to genetics vocabulary; Monohybrid crosses
  2. Dihybrid crosses
  3. Trihybrid crosses; Introduction to non-Mendelian genetics
  4. Mendelian and non-Mendelian genetics
  5. Chi-square test
  6. MID-TERM EXAM WEEK
  7. DNA isolation: Plasmid from bacterial cells (boiling method)
  8. DNA isolation: Plant sample (CTAB method)
  9. DNA isolation: Spider legs (Chelex method)
  10. Real-time PCR
  11. Real-time PCR: Result interpretation
  12. Preparation for practical exam
  13. Practical exam from lab course

TEACHING/ASSESSMENT
Description
  • Interactive Lectures
  • Practical Sessions
  • Excersises
  • Presentation
  • Problem solving
Description (%)
Method Quantity Percentage (%)
Midterm Exam(s)120
Laboratory120
Class Deliverables120
Final Exam140
Total: 100
Learning outcomes
  • Recall genetics terminology: homozygous, heterozygous, phenotype, genotype, homologous chromosome pair, etc.
  • Manage Mendelian genetics calculations
  • Assess non-Mendelian genetics
  • Critically discuss extranuclear inheritance
  • Interpret genetic mapping
  • Predict the genotype of cells that undergo mitosis and meiosis
  • Integrate concepts of genetic processes in plants and animals
TEXTBOOK(S)
  • Griffiths, A. J. F., Wessler, S. R., Carroll, S. B., & Doebley, J. (2010). Introduction to Genetic Analysis, 10th ed. New York, USA: W.H. Freeman

ECTS (Allocated based on student) WORKLOAD
Activities Quantity Duration (Hour) Total Work Load
Lecture (14 weeks x Lecture hours per week)15345
Laboratory / Practice (14 weeks x Laboratory/Practice hours per week)15230
Midterm Examination (1 week)122
Final Examination(1 week)122
Preparation for Midterm Examination11515
Preparation for Final Examination11515
Assignment / Homework/ Project12020
Seminar / Presentation12020
Total Workload: 149
ECTS Credit (Total workload/25): 6